BIOVIAMolecular Modeling
Protein Homology Modeling
This course introduces students to the theory of protein homology modeling and the tools available within Discovery Studio. Methods for selecting a protein template structure, aligning the template protein sequence to the target sequence, building the homology model, and assessing the quality of the protein structural model within the Discovery Studio framework are described. Methods available for refining the protein model within Discovery Studio are presented.
- Level
- Fundamental
- Length
- 8 hours
- Product
- Discovery Studio
- Delivery
- Instructor-led
Topics covered
- Assessing the limitations and assumptions in protein homology modeling
- Selecting an appropriate protein structural template to create a model
- Aligning your protein target sequence to a protein template sequence
- Building a protein homology model using Discovery Studio 2016 tools
- Analyzing the model in terms of quality, energy and structural features
- Refining the homology model
- Using the homology model for further studies, including mutagenesis studies, protein-protein docking, or ligand docking for structure-based drug design
Prerequisites
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